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Practical management considerations include: Dose review: If the heart rate increase is dose-dependent and symptomatic, reducing the dose or slowing the titration schedule where permitted by the trial protocol may help mitigate the effect whilst preserving therapeutic benefit
Being clear about this upfront helps set expectations that match reality, which in turn makes it easier to judge whether a product is genuinely working
Still learning and still showing up
Evening injection (8 to 10 PM) allows you to sleep through the initial peak
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